Intraperitoneal sodium thiosulfate for the treatment of calciphylaxis.
نویسندگان
چکیده
Calcific uremic arteriolopathy (or calciphylaxis) is a severe complication of renal failure characterized by subcutaneous calcification of the small arteries and tissue necrosis. We describe the case of a woman receiving continuous cycling peritoneal dialysis with calciphylaxis involving upper and lower extremities. After intolerance of intravenous sodium thiosulfate and limited intravenous access options, we administered sodium thiosulfate intraperitoneally and quantitated the amount of extra calcium removed. Intraperitoneal administration of sodium thiosulfate was well tolerated and led to removal of extra calcium with peritoneal dialysis.
منابع مشابه
Sodium Thiosulfate: An Emerging Treatment for Calciphylaxis in Dialysis Patients
Calciphylaxis is a rare but life-threatening complication seen in dialysis patients. We report a case with calciphylaxis and severe secondary hyperparathyroidism. Sodium thiosulfate (STS) was used for treatment in this case. The painful skin ulcers improved significantly soon after treatment, with a slight reduction in the calcium-phosphorus product. Total parathyroidectomy was carried out 6 mo...
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Introduction: Nonuremic calciphylaxis, a rare disorder with high mortality, is associated with severe calcifications of the media of arterioles which cause vascular occlusion and tissue necrosis. Case Report: A nonuremic calciphylaxis of the lower limb, possibly caused by coumarin therapy for atrial fibrillation. Treatment consisting of coumarin avoidance, vitamin K supplementation and thrice...
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BACKGROUND Calciphylaxis is a rare, yet life-threatening disease mainly occurring in dialysis patients. Traditional options of treatment remain unsatisfactory. METHODS Here we present a novel, combined approach, treating calciphylaxis with IV sodium thiosulfate, cinacalcet and sevelamer. In a case series five hemodialysis patients, have been successfully treated with this regimen. Treatment a...
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INTRODUCTION Calciphylaxis is a rare but dreadful complication of chronic kidney disease. It is characterized by nodular subcutaneous calcification and painful tissue necrosis which often results in ulceration and secondary infection, leading to a high rate of mortality. Pathogenesis of this disease is not well understood and there are very few, poorly studied treatment options for this disease...
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INTRODUCTION In clinical situations, vascular calcification tends to progress and is difficult to completely arrest or reverse. Calciphylaxis, a severe complication of end-stage renal disease, is a specific form of vascular calcification. Control studies have provided evidence that monotherapy with sodium thiosulfate or cinacalcet delays the progression of vascular calcification. Successful tre...
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عنوان ژورنال:
- Renal failure
دوره 28 4 شماره
صفحات -
تاریخ انتشار 2006